Additive Effects of Serotonin Transporter and Tryptophan Hydroxylase-2 Gene Variation on Emotional Processing
نویسندگان
چکیده
منابع مشابه
Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on emotional processing.
Prior studies reported that functional variants of both the serotonin transporter (5-HTT) and tryptophan hydroxylase-2 genes (TPH2), 2 key regulators of the serotonergic signaling pathway, modulate amygdala activation during emotional processing. We addressed the question whether these 2 gene variants modulate each other, using an emotional picture-processing task. Specifically, we measured eve...
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Variation in the tryptophan hydroxylase-2 gene (TPH2) coding for the rate-limiting enzyme of serotonin (5-HT) synthesis in the brain modulates responses of limbic circuits to emotional stimuli and has been linked to a spectrum of clinical populations characterized by emotional dysregulation. Here, we tested a set of common single nucleotide polymorphisms (SNPs) in and downstream of the transcri...
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Polymorphism at the serotonin transporter linked polymorphic region (5-HTTLPR) has been associated with neuroticism, increased risk for affective disorders and greater vulnerability to mood change following serotonin (5-HT) depletion. The aim of the present study was to investigate whether the cognitive effects of 5-HT depletion were differentially affected by genotype at the 5-HTTLPR polymorph...
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ژورنال
عنوان ژورنال: Cerebral Cortex
سال: 2006
ISSN: 1047-3211,1460-2199
DOI: 10.1093/cercor/bhl026